Journal: BMC Cancer

Article Title: Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival

doi: 10.1186/s12885-025-14455-8

Figure Lengend Snippet: EpCAM expression is predominantly observed in epithelial cells and related tissues. A - B , RNA and protein expression levels of EpCAM, based on data from Protein Atlas ( www.proteinatlas.org ), and GTEx Portal ( https://gtexportal.org/ ) are shown, with expression ranked from high to low. C EpCAM expression is elevated in tumor tissues compared to normal tissues, as analyzed using two independent tumor-normal paired datasets: GSE18842 and HSE1007. D Analysis of EpCAM expression across different stages of NSCLC and in relation to EGFR, KRAS, and ALK oncogenic alterations. Microarray datasets GSE43580 and GSE31210 were normalized and visualized using GraphPad. These results highlight that EpCAM expression is largely confined to normal epithelial tissues, including the gastrointestinal tract, thyroid, kidney, pancreas, breast, and lung, and is significantly upregulated in cancer tissues

Article Snippet: Microarray datasets GSE43580 and GSE31210 were normalized and visualized using GraphPad.

Techniques: Expressing, Microarray